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UB lab powering Thermo Fisher’s Alzheimer’s research
Overview
For decades, Alzheimer’s research was frustrated by a fundamental technical limitation: the brain is extraordinarily complex, and the location-specific molecular clues that matter most often exist at levels too low to measure in isolation.The research lab of University at Buffalo professor Jun Qu is powering Thermo Fisher Scientific’s advanced research into Alzheimer’s.
Specifically, Qu’s lab used technology developed by Thermo Fisher to identify early, region-specific changes in Alzheimer’s-related proteins that traditional analysis could not detect.
The maps generated by Qu’s lab could provide new insight into Alzheimer’s and help improve drug target selection in future therapy development.
In This Article
Researchers at SUNY Buffalo generated the first high-resolution, whole-brain spatial proteomics maps of Alzheimer’s disease, tracking how proteins change across different brain regions.
The research using Orbitrap Astral from Thermo Fisher identified early, region-specific changes in tau phosphorylation and other Alzheimer’s-related proteins that traditional bulk tissue analysis could not detect. These spatial protein maps provide new insight into Alzheimer’s disease and may help improve drug target selection in future therapy development.
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